setup-e1-remote-tool

Set up Profluent E1 as a remote tool

Validation status (2026-10-01): Profluent E1 600m ran on the NVIDIA GB10 (aarch64, cc 12.1) with the optimization kit OFF -- stock E1, and the only reachable configuration here rather than a fallback: flash-attn publishes no aarch64 build for this torch, and the kit's accelerator proof demands the literal string 2.8.0+cu128, which no aarch64 environment can satisfy because no CUDA build of torch 2.8.0 exists for this architecture at all (only +cu129). Verified on FOUR CONSECUTIVE IDENTICAL REQUESTS plus a mixed-shape sequence in one held worker: scoring in 0.075-0.080 s per request after a 12 s first call, peak reserved 4.30 GiB at 100 residues rising only to 4.84 at 800. That is the flattest ladder of any provider here -- 1.13x over 8x the length -- because E1 caps its batch at 65,536 tokens, so doubling the parent halves the batch. Public publication, cross-user isolation, concurrency, recovery and scoring quality are untested; keep this deployment private.

Prerequisites

• Run from the ToolUniverse repository root on Linux with Python 3.12.3.
• A CUDA GPU is required. This provider holds its model resident between requests; CPU is not a target.
• Keep provider data, weights, caches, and credentials outside Git.
• Bind to loopback. A non-loopback bind requires TOOLUNIVERSE_API_TOKEN; never put it in arguments or results.

Run the standard-library contract check before downloading large dependencies:

python scripts/remote_validation/setup_skill_preflight.py --implementation e1

After exporting provider resources, add --check-provider-env. After the server starts, add --live to verify the exact MCP tool set without running the model. Before sharing, add --check-connect-prereqs; this reports only whether a key is set and never prints its value.

Create the two environments

This provider is on the remote-tool standard, so it has two environments, not one: the MCP server runs in ToolUniverse's, and the model runs in its own, built from a pinned lock. They cannot import each other, and that is the point -- the model's stack is not installable beside ToolUniverse's.

python3 -m venv .venvs/e1
. .venvs/e1/bin/activate
python -m pip install --upgrade pip
python -m pip install -e .
python -m pip install fastmcp

The model half lives at the path TOOLUNIVERSE_E1_PYTHON names, and nothing above creates it. Create an empty interpreter there first -- python3 -m venv ~/e1-venv, or uv venv unless this provider's lock header says otherwise -- and tu remote setup --only environment fills it from src/tooluniverse/remote/e1/environment/requirements.lock with --no-deps, so no version is silently resolved to something else.

The rest is built by tu remote setup, which reads src/tooluniverse/remote/e1/provider.toml and runs five steps: preflight, environment, kit, weights, smoke. Each refuses by name and carries its fix.

export HF_HOME=...
export TOOLUNIVERSE_E1_PYTHON=~/e1-venv/bin/python
tu remote setup e1

Run one step at a time with --only preflight|environment|kit|weights|smoke while bringing a machine up. The smoke step is the one that matters: it holds the model, sends one request, asserts the provider produced what its manifest says a successful run produces, and records the measured peak VRAM to ~/.cache/tooluniverse/measured/e1.json. A host schedules on that file.

Package/network-dependent commands must be rerun in a clean environment before marking this skill complete.

Obtain credentials, data, and model weights

• HF_HOME points at the Hugging Face cache holding the three pinned Profluent-Bio/E1-* snapshots and the kernels-community/triton-layer-norm hub kernel (2.0 GiB total). No other provider holds any of it -- unlike ESM Cambrian, which reuses ESMFold2's download -- so this one fetches its own.
• Nothing is fetched at request time. The manifest declares every weight file with its size and sha256, and the launch refuses if one is off its pin.

Authorize once, then share with one short command

After installing dependencies, exporting the provider resources above, and installing the pinned relay SDK described under Connect below, run from the repository root. Log in only once per machine (and again after key rotation):

tu remote login
# Or import an existing protected 0600 file without sourcing it:
tu remote login --env-file /path/to/tooluniverse-service.env

Then each private share is one short command:

tu remote share e1

By default, tu remote login requests a short-lived device code, opens the TU Platform approval page, and polls until the signed-in user approves. No key copy/paste is required. On a headless machine, add --no-browser and open the printed link elsewhere. The CLI exchanges the approval for a computer-only key, verifies /remote-servers/preflight, stores it in a local 0600 config file, and never displays it.

The share command runs environment and TU Platform preflights, starts or reuses the exact loopback endpoint, validates discovery, and keeps the relay in the foreground until Ctrl-C. It automatically uses the reviewed Python, name, and worker count. Override them only when needed:

tu remote share e1 --name my-e1-remote --workers 1

Use tu remote check e1 for a non-sharing readiness check and tu remote run e1 for a local-only foreground server.

In an interactive terminal, sharing automatically starts the same browser flow when the key is missing, expired, or revoked. A malformed or revoked explicit TOOLUNIVERSE_SERVICE_KEY fails fast instead of being silently replaced; unset or correct it, then run tu remote login. Non-interactive jobs also fail fast. Use tu remote logout to remove only the local copy. Use tu remote logout --revoke to revoke the computer-only platform connection first; the server record remains offline for owner inspection.

Start and verify locally

python -m tooluniverse.remote.e1.e1_tool

The Streamable HTTP endpoint is http://127.0.0.1:8044/mcp. In a second activated shell run:

python - <<'PY'
import asyncio
from fastmcp import Client

async def main():
    async with Client("http://127.0.0.1:8044/mcp") as client:
        print([tool.name for tool in await client.list_tools()])

asyncio.run(main())
PY

Confirm discovery contains run_e1_score_variants; stop on empty, duplicate, or schema-drifted discovery.

The first request after a restart pays the model build; the ones after it do not. That is the whole reason this provider is resident, and a benchmark that measures only the first call measures the wrong thing.

Connect to ToolUniverse Connect

The tuplatform-connect relay is not yet published on PyPI. Install the reviewed public wheel below; its SHA-256 is pinned. Interactive sharing uses browser device authorization, so no key copy/paste or GitHub access is required.

python -m pip install fastmcp pyyaml "tuplatform-connect @ https://connect.aiscientist.tools/downloads/tuplatform_connect-0.3.0-py3-none-any.whl#sha256=3fad5eee5ecf7887a693d93ccd1aa112dc0955617a885d1fc3daded0030f9ae0"
tu doctor --forward http://127.0.0.1:8044/mcp --json
tu serve --share --forward http://127.0.0.1:8044/mcp --name validation-e1 --workers 1

Prefer browser device authorization. For CI or migration, supply TOOLUNIVERSE_SERVICE_KEY only through a protected environment or use tu remote login --manual-key; never put a key in shell arguments.

This implementation was added after the authenticated 2026-08-16 Platform matrix and was not part of it. That matrix imported each implementation it covered as unpublished owner drafts and invoked them through /expert-sessions/{id}/test; this provider was imported as no such draft and invoked through no such route. It has not been exercised through the Platform at all: the evidence above is local, on one card, through the loopback endpoint. Public publication, independent-caller authorization/isolation, saturation, and persistent supervision are untested.

Run a verified example

Operation: run_e1_score_variants

{"parent_sequence": "FWDKESRSPHESAPQYARKIWEMAAAVAPHQATIRSVINIIRLAQVEGLEMTQTHLLWSTPWCSIPQGNVND", "mutant_sequences": ">S6R\nFWDKERRSPHESAPQYARKIWEMAAAVAPHQATIRSVINIIRLAQVEGLEMTQTHLLWSTPWCSIPQGNVND\n>R18V\nFWDKESRSPHESAPQYAVKIWEMAAAVAPHQATIRSVINIIRLAQVEGLEMTQTHLLWSTPWCSIPQGNVND\n"}

Invoke the example through the live local MCP endpoint:

python - <<'PY'
import asyncio
import json
from fastmcp import Client

async def main():
    arguments = json.loads(r'''{"parent_sequence": "FWDKESRSPHESAPQYARKIWEMAAAVAPHQATIRSVINIIRLAQVEGLEMTQTHLLWSTPWCSIPQGNVND", "mutant_sequences": ">S6R\nFWDKERRSPHESAPQYARKIWEMAAAVAPHQATIRSVINIIRLAQVEGLEMTQTHLLWSTPWCSIPQGNVND\n>R18V\nFWDKESRSPHESAPQYAVKIWEMAAAVAPHQATIRSVINIIRLAQVEGLEMTQTHLLWSTPWCSIPQGNVND\n"}''')
    async with Client("http://127.0.0.1:8044/mcp") as client:
        result = await client.call_tool("run_e1_score_variants", arguments)
        print(result)

asyncio.run(main())
PY

Expected success shape: a scores array with one entry per mutant (the zero-shot masked-marginal log-likelihood ratio against the parent) and parent_length. Mutant ids must spell their own 1-based substitution and every record must be the parent's length; a mismatch is refused by name in the tool, before the GPU is touched. run_e1_embed returns the mean-pooled vector by default and hands the full per-residue matrix back as a path to a float32 .npy, never inline. Check scientific meaning, output bounds, invalid-input behavior, and absence of paths, secrets, and traces.

Tune GPU and concurrency

• Use one worker. The resident worker serves one request at a time by design; a second in-flight request queues on its lock rather than doubling peak VRAM.
• Read vram_budget_gb from the provider manifest and the measured file before co-tenanting anything else on the card. For a model whose peak depends on input size, the manifest states the envelope the figure was measured at; a larger request exceeds it.
• Measure cold start, then at least four consecutive identical requests, then a mixed-shape sequence (small, small, large, small). Two warm calls of different shapes is not enough: openfold3 passed exactly that and still died on the second request of the same shape, because a CUDA graph captured on the first replay attempt left a failed capture behind. A repeat and a shape change are different tests and a resident provider has to survive both.
• Then parallel levels 1, 2, 4, 8, and only 16 if memory permits.
• Record successes/errors, p50/p95, peak RAM/VRAM, utilization, queueing, cancellation cleanup, and recovery.
• Increase workers only after single-flight initialization and sanitized recoverable OOM/timeout behavior are proven.

Troubleshoot and clean up

• Read the refusal. Every step of tu remote setup names what is wrong and carries the fix; exit 3 is a refusal and exit 1 is a failure.
• The worker's own transcript is at ~/.cache/tooluniverse/remote-logs/e1-resident.log, and it holds the kit's full lever census. A lever reading state=off reason=... is the kit declining something, which is usually correct.
• Import/executable failure in the model half: re-run tu remote setup e1 --only environment. It rebuilds from the lock with --no-deps and will not silently resolve a different version.
• Weights off their pin: the named file is left in place for inspection rather than deleted, because a truncated transfer and a corrupt file look alike. Remove it by hand and re-run --only weights.
• 401/403 on deliberate network binding: configure matching TOOLUNIVERSE_API_TOKEN bearer auth; prefer loopback plus relay.
• Stop server/relay with Ctrl-C. If installed, run tuplatform-service uninstall --name validation-e1.
• A worker outliving its server is a known shape: it has an idle timeout and an orphan watchdog, and it exits when its parent becomes init. Check with nvidia-smi --query-compute-apps=pid,used_memory --format=csv before assuming the card is free.
• Revoke temporary keys. After confirmation, remove only .venvs/e1 and the provider's own cache directory; never use a broad recursive target.

Use only official upstream documentation linked by the implementation README; do not substitute third-party model mirrors.